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Title   성인 급성골수성 백혈병 환자의 관해후 장기 생존율에 영향을 미치는 예후인자 ( Prognostic Factors in Patients with Acute Myelogenous Leukemia ( AML ) who Achieve Primary Compltete Remission )
Publicationinfo   1993 Jan; 025(01): 67-78.
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Abstract   Background; With current induction chemotherapy, 60% to 80% of patients with acute my- elogenous leukemia(AML) can achieve their first remission, however, the duration of remission is short and only 20% to 30% of the patients can maintain long-term disease-free survival(DFS) after consolidation. Clinically relevant adverse prognostic features include increasing age, cytogenetic abnormality, presence of preleukemic syndrome, FAB classification, and evidence of extramedullary disease. To identify clinical factors for a good prognosis, we retrospectively analysed the age, sex, FAB subgroup, percent of leukemic blasts in day 7 bone marrow after initiation of remission induction chemotherapy, and numbers of consolidation chemotherapy. Mothods: 65 patients with AML entering complete remission from 121 patients who received intensive induction chemotherapy in St. Marys hospital from July 1986 until December 1991 were recruited for this retrospective study. The statistical analysis has attempted to define clinical factors predictive of either remission duration or survival rate. Results: 1) Among 65 patients entering complete remission, the 58 patients have been followed for 3 to 57 months(median: 21 months). 4-year survival rate of patients entering complete remissoin (n=65) was 24.4%, and probability of being in remission was 22.7%. 2) The number of postremission consolidation chemotherapy was the only significant prognostic factor influencing on long term disease free survivaL No significant correlation was observed between the probability of survival and age(40
저 자   민창기(Chang Ki Min),김희제(Hee je Kim),전두수(Doo Soo Jeon),진종률(Jong Youl Jin),이종욱(Chong Wook Lee),한치화(Chi Wha Han),민우성(Woo Sung Min),박종원(Chong Won Park),김춘추(Choon Choo Kim),김동집(Dong Jip Kim)